The National Biosafety Authority (NBA) receives, processes, responds to, and make decisions on applications under the Biosafety Act, 2011; it is expected to establish an administrative mechanism to ensure the appropriate handling and storage of documents and data in connection with applications and other matters covered under the Biosafety Act. Again, it acts as the National Focal Point responsible for liaising with any other agencies or international organizations concerned with biotechnology and biosafety and; lastly, to promote public awareness, participation, and education concerning the activities of the Authority under the Biosafety Act. 

To ensure an integrated approach to the regulation of modern biotechnology and its products, the Act mandates the Authority to operate in conjunction with other regulatory agencies such as the Food and Drugs Authority (FDA), Ghana Standards Authority (GSA), Customs Division of the Ghana Revenue Authority, the Environmental Protection Agency (EPA), Veterinary Directorate, the Plant Protection, and Regulatory Services Directorate (PPRSD) and the Ministry of Local Government and Rural Development. In addition, the Authority is represented by certified Institutional Biosafety Committees (IBCs) in research and academic institutions conducting research on Genetically Modified Organisms (GMOs) in Ghana. The Act has also established a Technical Advisory Committee (TAC) to support the Authority in conducting a risk assessment and management of GMOs and also to provide scientific advice to the Authority on issues under the Act. Furthermore, the Authority is supported by an Appeals Tribunal which deals with concerns of aggrieved persons on issues regarding applications and other matters under the Act.